Kevin Smith returns to direct another Supergirl and gets a heartbreaking one as we see the end of Sanvers. At the same time, Smith gets to helm an episode where Katie McGrath gets to shine as Lena Luthor.
Lena is in the spotlight in the episode and not in a good way. During a press conference, Morgan Edge is blaming a string children suffering from lead poisoning on Lena’s device to rid of the Daxamites. All of this comes to light when one of Ruby’s friend, Luke, collapses in front of her.
Lena and Kara go to the hospital to check on the children and run into Edge. Lena and Edge get into it but Edge still puts the blame on Lena for what befell the children.
Back at L Corp, Lena and James are still at odds first over her approving an editorial and he suggesting she step down while everything is going on. Kara thinks it is a bad idea but Lena agrees with James and steps down temporarily of CatCo and L Corp leaving James and Sam in charge respectively.
Not helping matters is Luke’s father (Bard on the Beach alum Bob Frazer) visits CatCo to yell at Lena for making his son sick. Lena calls a press conference (which the crowd yells “Lock her up”) to explain her side of things and tries to offer reassurances but a distraught mom shoots at Lena. James pushes her out of the way but gets hit in the shoulder for his troubles.
At the DEO, James and Winn try and get Kara to see that Lena is possibly to blame for this because she is a Luthor. Kara is determined to prove Lena’s innocence and has Winn test the device again to make sure that it was not responsible for causing the lead poisoning. Unfortunately, the test concludes that there is a 10% chance that the device could have been the culprit.
After the attemp on her life, Lena is crashing at Sam’s and is drinking her sorrows away. Kara drops by and tries to cheer Lena up but she tells Kara don’t bother with her as she is the one to blame. After Lena passes out, Kara and Sam investigate any links between the poisonings and traces it to a food truck that was at a Octoberfest event. The two head to the event’s location and see a nearby pool that all the kids may have swam in. Kara uses her x-ray vision and notices particles in the water. Using a DEO tester, she gets Winn to test the water samples and notices it is a synthetic compound that when it touches water can mimic the symptoms of lead poisoning.
Kara and Sam them find a store room full of chemicals from Acre Lee Chemical. Kara phones Lena to tell her she is not at fault and mentions finding Acre Lee Chemical. Lena pretends to not recognize the name but she knows that Edge is behind the company. Lena goes to confront Edge for framing her but one of his goons knocks her out and she ends up on a plane.
The plane is filled with Acre Lee Chemicals and headed towards the water reservoir. Edge plans on dumping the chemicals into National City’s water source to poison everyone. Lena notices that plan is on auto pilot and we see one of Edge’s men controlling it on the ground. The DEO is alerted to an unidentified plane in the sky and also to Lena’s distress call before Edge cuts it out.
Edge attempts to dump the barrels of chemicals but Lena stops it from falling. So Edge decides to crash the plane. Luckily, Supergirl arrives and causes the plane to break in half. One half had Lena the other half has the chemicals. Lena tells Supergirl to save the chemicals and let her go. Supergirl refuses and tells Lena to climb to her. Supergirl catches Lena and brings down the plane safely. Edge gets his henchman to shoot the console and then kills him.
This allowed Edge to blame his henchman was a lone wolf with a vendetta against the Luthor family when confronted by Supergirl. Supergirl can’t understand why Edge would frame Lena and can’t believe he hates her that much. Edge tells Supergirl that she doesn’t have what it takes to be ruthless.
Back at Sam’s, Lena is thankful for having friends like Sam and Kara for believing in her. Sam and Kara re-affirm their friendship and sisterhood with Lena. Their celebration is cut short when Alex calls Kara for support.
We find out why Alex needs her sister. After thwarting a prison break, Kara tells Alex that she will be fine as she faces what’s to come with her relationship with Maggie.
At Alex’s, Alex finally tells Maggie her desire to be a mom. Alex asks if Maggie will ever change her mind about wanting children. Maggie doesn’t answer and this forces Alex to say they shouldn’t be together.
Alex is packing Maggie’s things when Maggie plays some Cyndi Lauper and the two dance. They end up kissing that leads up to break-up sex. In the after glow, Maggie wonders why they are breaking up and Alex tells her a story of when she realized she wants to be a mom. As a result, nothing has changed between the two and they tearfully part but not before they tell each other how much their relationship has meant to them and changed them for the better. As Maggie leaves, we see their two engagement rings on the table.
So this brings us to Kara finding Alex in a bar drowning her sorrows. Kara then tells Alex they are going on a road trip to go home to Midvale for a few days to get away from everything.
In the coda, Ruby notices that Sam has a hole in her shirt. Sam clues in that she may have been hit during the press conference and it is confirmed when she finds the bullet all crumpled but not a scratch on her.